| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Serca2 deletion in the mouse adult Bmi1+ compartment induces a lethal phenotype involving a severe gastric dysfunction
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Diego Herrero, Antonio Docavo, Maria Salvador, Marina Higuera, Alfonso Cortés, Javier García-Ceca, Sara Montero-Herradón, Miguel A García-Brenes, Guillermo Albericio, Alejandra Cordero, Rosa M Carmona, Antonio de Molina, JM Salvador, Carmen Mora, Agurtin G Zapata and Antonio Bernad |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Spanish Ministry of Science and Innovation, AEI/FEDER, UE |
No. RTI2018-097604-B-I00 |
| The Instituto de Salud Carlos III, Cell Therapy Network, TERCEL |
No. RD16/0011/0037 |
| The Spanish Ministry of Science, Innovation and Universities |
No. RTI2018-093938-B-I00 |
| The Carlos III Health Institute, Cell Therapy Network, TERCEL |
No. RD16/0011/0002 |
| The program has been funded by the Regional Government of Madrid Program, Avancell |
No. B2017/BMD-3692 |
|
| Corresponding Author |
Antonio Bernad, Department of Immunology and Oncology, National Center for Biotechnology (CNB.CSIC), C/Darwin 3 Universidad Autonoma de Madrid Campus de Cantoblanco, Madrid 28049, Spain. abernad@cnb.csic.es |
| Key Words |
Bmi1; Adult stem cell; Serca2; Calcium ions regulation; Small intestine; Crypts; Intestinal stem cell |
| Core Tip |
Although cytoplasmic [calcium ions (Ca2+)] plays an important role in regulating several critical cellular processes, low information is available regarding intestinal stem cells (ISC). Recent seminal results, obtained in Drosophila melanogaster, have demonstrated that the reduction of Ca2+ in ISC increases their proliferation rate; downregulation of Serca is one of the main genes involved. Based on these relevant results, and taking advantage of a dedicated mouse models, we have demonstrated that the deletion of Serca2 in the intestinal Bmi1+ populations provokes, unexpectedly, a lethal phenotype, associated with a severe malnutrition. Furthermore, because this promotes ISC proliferation rate a moderate reduction of Serca2 activity could be involved in some neoplasic conditions. |
| Citation |
Herrero D, Docavo A, Salvador M, Higuera M, Cortés A, García-Ceca J, Montero-Herradón S, García-Brenes MA, Albericio G, Cordero A, Carmona RM, de Molina A, Salvador J, Mora C, Zapata AG, Bernad A. Serca2 deletion in the mouse adult Bmi1+ compartment induces a lethal phenotype involving a severe gastric dysfunction. World J Gastroenterol 2026; In press |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
