Publication Name	World Journal of Gastroenterology
Manuscript ID	113024
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Danggui-Baishao herb pair protects against dextran sulfate sodium-induced colitis by modulating the Wnt/β-catenin pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Tian Xu, Wei-Xin Hou, Sun-Ting Yang, Yu-Pei Shao, Jing Wang, Tao-Tao Han and Jing-Nan Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82405050 National Natural Science Foundation of China 8227034002 National Natural Science Foundation of China 8210035244 Fundamental Research Funds for the Central Universities, China 3332024017
Corresponding Author	Jing-Nan Li, Department of Gastroenterology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China. jnli2020@126.com
Key Words	Danggui-Baishao herb pair; Benzoylpaeoniflorin; Ulcerative colitis; Wnt/β-catenin pathway; Intestinal barrier; Gut microbiota; Bile acids
Core Tip	The Danggui-Baishao herb pair has shown definite anti-colitis effects in traditional Chinese medicine. By detecting the active ingredients of the herb pair and using transcriptome sequencing for mechanism prediction, our results show that the herb pair protects against colitis by activating the Wnt/β-catenin pathway in vivo, yet this effect is diminished by the β-catenin antagonist ICG-001. Through metabolomics, 16S rRNA, and metagenomic further revealed that the herb pair regulates bile acids metabolism and gut microbiota composition. Finally, molecular docking revealed that benzoylpaeoniflorin has a structural basis for binding to β-catenin. Benzoylpaeoniflorin can activating the Wnt/β-catenin pathway in vitro and diminished by the ICG-001. This study provides experimental evidence for research on anti-colitis drugs.
Citation	Xu T, Hou WX, Yang ST, Shao YP, Wang J, Han TT, Li JN. Danggui-Baishao herb pair protects against dextran sulfate sodium-induced colitis by modulating the Wnt/β-catenin pathway. World J Gastroenterol 2025; In press

Received	2025-08-18 08:02
Peer-Review Started	2025-08-18 08:02
First Decision by Editorial Office Director	2025-09-23 09:49
Return for Revision	2025-09-23 09:49
Revised	2025-10-15 14:11
Publication Fee Transferred	2025-10-17 01:53
Second Decision by Editor	2025-12-08 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-08 06:50
Articles in Press	2025-12-08 06:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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