Publication Name	World Journal of Cardiology
Manuscript ID	113066
Country	Italy

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Case Report
Article Title	From COVID-19 to influenza A - recurrent viral myocarditis and successful immunosuppressive therapy: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Lucia Ilaria Birtolo, Federico Ferranti, Giovanna Manzi, Annalisa Caputo, Gianmarco Scoccia, Katia Bruno, Nicola Galea, Viviana Maestrini, Cristina Chimenti, Paolo Severino, Francesco Pugliese, Roberto Badagliacca and Carmine Dario Vizza
Funding Agency and Grant Number
Corresponding Author	Lucia Ilaria Birtolo, MD, PhD, Department of Clinical, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Lazio, Italy. luciailaria.birtolo@uniroma1.it
Key Words	Myocarditis; COVID-19; Influenza A; Immunosuppressive therapy; Corticosteroids; Veno-arterial extracorporeal membrane oxygenation; Cardiac magnetic resonance; Genetic predisposition; Case report
Core Tip	We present the case of a young woman who experienced two episodes of fulminant viral myocarditis following distinct viral infections (severe acute respiratory syndrome coronavirus 2 and influenza A), both of which were successfully treated with high-dose corticosteroids. The case raises key questions about the role of immunosuppressive therapy in managing the immune activation triggered by viral infections in myocarditis. The recurrence in the same patient highlights the importance of investigating possible underlying genetic or autoimmune vulnerabilities. This report provides insights that enhance our understanding of the complex relationship between viral triggers, immune response, and patient susceptibility in cases of myocarditis.
Citation	Birtolo LI, Ferranti F, Manzi G, Caputo A, Scoccia G, Bruno K, Galea N, Maestrini V, Chimenti C, Severino P, Pugliese F, Badagliacca R, Vizza CD. From COVID-19 to influenza A - recurrent viral myocarditis and successful immunosuppressive therapy: A case report and review of literature. World J Cardiol 2026; In press

Received	2025-08-14 03:17
Peer-Review Started	2025-08-14 03:17
First Decision by Editorial Office Director	2025-09-01 08:26
Return for Revision	2025-09-01 08:26
Revised	2025-09-14 16:39
Publication Fee Transferred	2026-04-21 10:26
Second Decision by Editor	2026-05-08 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-08 07:24
Articles in Press	2026-05-08 07:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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