Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	113096
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Hereditary angioedema with recurrent abdominal pain in a patient with a novel SERPING1 gene mutation: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Ko Matsuura, Chie Ueda, Chinami Hashimura, Hiromasa Yakushiji and Takahiko Horiuchi
Funding Agency and Grant Number
Corresponding Author	Ko Matsuura, MD, Department of Gastroenterology, Kishiwada Tokushukai Hospital, 4-27-1 Kamori-cho, Kishiwada 596-0042, Osaka, Japan. matuurac90@gmail.com
Key Words	C1 inhibitor; Complement C4; SERPING1 gene; Frameshift mutation; Hereditary angioedema; Gastrointestinal edema; Case report
Core Tip	This study highlights that hereditary angioedema should be considered in cases of recurrent abdominal pain, even in the absence of typical edema or family history. Although the initial presentation mimicked acquired angioedema, the early onset prompted SERPING1 gene testing, revealing a novel frameshift mutation. This case emphasizes the importance of genetic confirmation for hereditary angioedema diagnosis in atypical cases, as timely diagnosis is crucial owing to the potentially life-threatening nature of the condition.
Citation	Matsuura K, Ueda C, Hashimura C, Yakushiji H, Horiuchi T. Hereditary angioedema with recurrent abdominal pain in a patient with a novel SERPING1 gene mutation: A case report. World J Gastrointest Endosc 2026; In press

Received	2025-08-27 11:26
Peer-Review Started	2025-08-27 11:27
First Decision by Editorial Office Director	2025-09-03 06:45
Return for Revision	2025-09-03 06:45
Revised	2025-11-20 09:30
Publication Fee Transferred	2025-11-21 01:48
Second Decision by Editor	2026-02-02 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 02:28
Articles in Press	2026-02-03 02:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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