Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	113099
Country	Croatia

Category	Oncology
Manuscript Type	Case Report
Article Title	Patients with hepatocellular carcinoma achieving a complete response to sorafenib: Three case reports and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Hana Lučev, Gordan Adžić, Stjepko Pleština and Juraj Prejac
Funding Agency and Grant Number
Corresponding Author	Gordan Adžić, MD, Department of Oncology, University Hospital Centre Zagreb, Kišpatićeva 12, Zagreb 10000, Croatia. gordan.adzic@gmail.com
Key Words	Hepatocellular carcinoma; Sorafenib; Complete response; Tyrosine kinase inhibitor; Case report
Core Tip	Complete responses to sorafenib in advanced hepatocellular carcinoma are extremely rare. This case series reports 3 patients who, despite having advanced hepatocellular carcinoma with features like portal vein thrombosis and extrahepatic spread, achieved durable complete responses on sorafenib therapy. Predictive biomarkers for sorafenib response remain unknown, although dermatologic toxicity and non-viral etiology may be associated with favorable outcomes. These findings support the continued utility of tyrosine kinase inhibitors in selected patients, particularly when immunotherapy is contraindicated or unavailable.
Citation	Lučev H, Adžić G, Pleština S, Prejac J. Patients with hepatocellular carcinoma achieving a complete response to sorafenib: Three case reports and review of literature. World J Gastrointest Oncol 2025; In press

Received	2025-08-15 04:41
Peer-Review Started	2025-08-15 04:42
To Make the First Decision
Return for Revision	2025-09-12 05:34
Revised	2025-09-21 13:15
Second Decision	2025-11-20 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-20 10:52
Articles in Press	2025-11-20 10:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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