Publication Name	World Journal of Psychiatry
Manuscript ID	113121
Country	South Korea

Category	Psychiatry
Manuscript Type	Letter to the Editor
Article Title	Synthesizing the risk of postoperative delirium in organ transplantation
Manuscript Source	Unsolicited Manuscript
All Author List	Haewon Byeon
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation of Korea No. RS-2023-00237287
Corresponding Author	Haewon Byeon, Associate Professor, Director, PhD, Worker's Care and Digital Health Laboratory, Department of Future Technology, Korea University of Technology and Education, 1600 Chungjeol-ro, Cheonan 31253, South Korea. bhwpuma@naver.com
Key Words	Postoperative delirium; Organ transplant; Risk factors; Statistical heterogeneity; Model for end-stage liver disease/acute physiology and chronic health evaluation II scores
Core Tip	The meta-analysis by Hou et al provides a crucial summary, establishing a 20% overall incidence of postoperative delirium in organ transplant patients, with rates varying significantly by organ. Key risk factors identified, such as primary graft dysfunction and high model for end-stage liver disease/acute physiology and chronic health evaluation II scores, offer actionable targets for clinical prevention. However, the study's substantial heterogeneity and the unexpected non-significance of age as a risk factor highlight the limitations of pooling diverse studies. This commentary emphasizes that while the meta-analysis is a valuable evidence synthesis, its findings should be interpreted with caution, paving the way for future prospective, organ-specific research with standardized protocols to develop robust clinical tools.
Citation	Byeon H. Synthesizing the risk of postoperative delirium in organ transplantation. World J Psychiatry 2025; In press

Received	2025-08-15 04:27
Peer-Review Started	2025-08-15 04:27
To Make the First Decision
Return for Revision	2025-09-07 02:43
Revised	2025-09-08 02:24
Second Decision	2025-10-11 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-11 06:12
Articles in Press	2025-10-11 06:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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