Publication Name	World Journal of Biological Chemistry
Manuscript ID	113144
Country	India

Category	Chemistry, Medicinal
Manuscript Type	Basic Study
Article Title	Study of Tinospora cordifolia stem and Senna siamea leaf and pods: An in vitro therapeutic approach in leukemia
Manuscript Source	Invited Manuscript
All Author List	Arthi Boro, Abidharini Jothi Dheivasikamani, Antony Prabhu Jeyabal Philomenathan, Jeganathan Manivannan, Sujatha Krishnaswamy, Sampathkumar Palanisamy and Vijaya Anand Arumugam
Funding Agency and Grant Number
Corresponding Author	Vijaya Anand Arumugam, Department of Human Genetics and Molecular Biology, Bharathiar University, Maruthamalai Road, Coimbatore 641046, Tamil Nadu, India. avahgmb@buc.edu.in
Key Words	Tinospora cordifolia; Senna siamea; Quantitative analysis; Enzymatic activity; Therapeutic approach
Core Tip	The following study focuses on the identification of therapeutic properties of the aqueous extracts of Tinospora cordifolia stem and Senna siamea pods and leaf in leukemia cell lines. Both plants are found to contain therapeutic properties and are also found to be a potential treatment for myeloid leukemia due to an induction of apoptosis by an increase in reactive oxygen species activity, which causes a reduction in mitochondrial membrane potential. The following study was carried out in vitro and needs further in vivo and clinical study to come to a conclusion.
Citation	Boro A, Dheivasikamani AJ, Philomenathan APJ, Manivannan J, Krishnaswamy S, Palanisamy S, Arumugam VA. Study of Tinospora cordifolia stem and Senna siamea leaf and pods: An in vitro therapeutic approach in leukemia. World J Biol Chem 2026; In press

Received	2025-08-18 01:51
Peer-Review Started	2025-08-18 01:51
First Decision by Editorial Office Director	2025-09-12 06:28
Return for Revision	2025-09-12 06:28
Revised	2025-09-24 07:32
Publication Fee Transferred
Second Decision by Editor	2026-01-28 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-28 07:37
Articles in Press	2026-01-28 07:37
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8454 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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