Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	113150
Country	Morocco

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Shifting paradigm in locally advanced resectable gastric and gastroesophageal junction cancers
Manuscript Source	Unsolicited Manuscript
All Author List	Nabil Ismaili
Funding Agency and Grant Number
Corresponding Author	Nabil Ismaili, Associate Professor, Chief Physician, Director, MD, Department of Medical Oncology, Mohammed VI Faculty of Medicine, Mohammed VI University of Health Sciences, Boulevard Mohammed Taieb Naciri, Commune Hay Hassani, Casablanca 20000, Morocco. ismailinabil@yahoo.fr
Key Words	Gastric cancer; Locally advanced; Perioperative therapy; Chemotherapy; Immunotherapy
Core Tip	The recent real-world study by Wang et al adds to the growing evidence that perioperative sintilimab combined with oxaliplatin and S-1 chemotherapy improves pathological response and overall survival in non-metastatic gastric cancer, with a manageable safety profile. However, the conclusions are tempered by the study’s retrospective design, limited power, and the use of a potentially suboptimal chemotherapy backbone. Crucially, this data aligns with the positive results of the large phase III MATTERHORN trial, solidifying the paradigm shift. The collective evidence now strongly suggests that adding immunotherapy to perioperative chemotherapy enhances cure rates for locally advanced resectable gastric and gastroesophageal junction cancers, establishing this combination as a new standard of care.
Citation	Ismaili N. Shifting paradigm in locally advanced resectable gastric and gastroesophageal junction cancers. World J Gastrointest Oncol 2025; In press

Received	2025-08-18 02:31
Peer-Review Started	2025-08-18 02:31
To Make the First Decision
Return for Revision	2025-10-27 09:12
Revised	2025-10-28 07:59
Second Decision	2025-11-27 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-27 04:03
Articles in Press	2025-11-27 04:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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