Publication Name	World Journal of Gastroenterology
Manuscript ID	113181
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Anwei decoction alleviates chronic atrophic gastritis by modulating the gut microbiota-metabolite axis and NLRP3 inflammasome activity
Manuscript Source	Unsolicited Manuscript
All Author List	Hong Qin, Yi-Yang Liu, Qiang Li, Sai-Yan Wei, Li-Yun Huang, Chai-Feng Zhou, Li-Yan Tan, Jing-Wen Zhang, De-Kun Wu and You-Ming Tang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 81860843 Guangxi Administration of Traditional Chinese Medicine Project No. GZSY23-36 Guangxi Administration of Traditional Chinese Medicine Project No. GXZYA20240150
Corresponding Author	De-Kun Wu, Associate Professor, Professor, Teaching Experiment and Training Center, Guangxi University of Chinese Medicine, No. 179 East Mingxiu Road, Xixiangtang District, Nanning 530000, Guangxi Zhuang Autonomous Region, China. 1278323777@qq.com
Key Words	Anwei decoction; Chronic atrophic gastritis; Gut microbiota-metabolite axis; NLRP3 inflammasome; Traditional Chinese medicine
Core Tip	Chronic atrophic gastritis (CAG) is a precancerous lesion of the stomach, with a prevalence of 34.7% in China and a risk of gastric cancer that is 4 times that of ordinary people. Existing therapies have high side effects and cannot reverse pathological damage. Traditional Chinese medicine Anwei decoction inhibits NLRP3 inflammasomes, reshapes the balance of microflora, breaks through the limitations of single targets, and provides a new strategy for CAG treatment, which can delay cancer and reverse pathological damage through the regulation of the “microbiota-metabolism-immunity” network.
Citation	Qin H, Liu YY, Li Q, Wei SY, Huang LY, Zhou CF, Tan LY, Zhang JW, Wu DK, Tang YM. Anwei decoction alleviates chronic atrophic gastritis by modulating the gut microbiota-metabolite axis and NLRP3 inflammasome activity. World J Gastroenterol 2025; In press

Received	2025-08-25 06:05
Peer-Review Started	2025-08-25 06:06
To Make the First Decision
Return for Revision	2025-09-22 09:37
Revised	2025-10-03 17:34
Second Decision	2025-11-17 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-17 06:18
Articles in Press	2025-11-17 06:18
Publication Fee Transferred	2025-10-07 13:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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