Publication Name	World Journal of Gastroenterology
Manuscript ID	113187
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Stemness CD24 activation promotes hepatocellular carcinoma progression via an immune escape mechanism
Manuscript Source	Unsolicited Manuscript
All Author List	Yin Cai, Lu-Yin Liu, Xiao-Xiao Xia, Hao Tang, Min Xu, Wen-Li Sai, Deng-Fu Yao and Min Yao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 32470985 Nantong S & T Programs of China MS2024051 Federation for Prevention & Control of Infectious Diseases of China NTCRB2025016
Corresponding Author	Min Yao, PhD, Postdoc, Professor, Department of Immunology, Medical School of Nantong University, Nantong University, No. 19 Qixiu Road, Nantong 226001, Jiangsu Province, China. erbei@ntu.edu.cn
Key Words	Clusters of differentiation 24; Hepatocarcinogenesis; Programmed death-ligand 1; Biomarker; Chronic liver disease
Core Tip	Upregulated clusters of differentiation 24 (CD24) expression is associated with hepatocellular carcinoma progression. CD24, a marker of liver cancer stem cells, might exert its oncogenic regulatory effects on the malignancy of chronic liver diseases through the activation of programmed death-ligand 1 signaling. Clinical investigations and hepatocarcinogenesis models have confirmed that upregulated CD24 promotes hepatocyte malignancy via immune escape mechanisms and could be a favorable biomarker for monitoring hepatocarcinogenesis.
Citation	Cai Y, Liu LY, Xia XX, Tang H, Xu M, Sai WL, Yao DF, Yao M. Stemness CD24 activation promotes hepatocellular carcinoma progression via an immune escape mechanism. World J Gastroenterol 2025; In press

Received	2025-08-19 02:15
Peer-Review Started	2025-08-19 02:16
To Make the First Decision
Return for Revision	2025-08-27 09:50
Revised	2025-09-10 07:03
Second Decision	2025-11-26 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-26 06:42
Articles in Press	2025-11-26 06:42
Publication Fee Transferred	2025-09-11 03:46
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com