Publication Name	World Journal of Methodology
Manuscript ID	113191
Country	India

Category	Medical Laboratory Technology
Manuscript Type	Letter to the Editor
Article Title	Advancing chronic low back pain management: Insights from amitriptyline and duloxetine comparison
Manuscript Source	Invited Manuscript
All Author List	Shree Rath
Funding Agency and Grant Number
Corresponding Author	Shree Rath, MD, Department of Medicine, All India Institute of Medical Sciences Bhubaneswar, Sijua, Patrapada, Bhubaneswar 751019, Odisha, India. shreerath4a@gmail.com
Key Words	Chronic low back pain; Amitriptyline; Duloxetine; Visual analog scale; Sedatives
Core Tip	This manuscript highlights the comparative effectiveness of amitriptyline and duloxetine for chronic low back pain (CLBP). While amitriptyline provides rapid early pain relief, duloxetine offers more durable reduction with fewer side effects, making it preferable for sustained management. The study’s real-world approach, using robust statistical adjustments and patient-centered outcomes, emphasizes the importance of personalized treatment strategies in chronic pain. These findings support duloxetine as a promising option and underscore the need for further randomized trials to refine evidence-based guidelines for CLBP management.
Citation	Rath S. Advancing chronic low back pain management: Insights from amitriptyline and duloxetine comparison. World J Methodol 2025; In press

Received	2025-08-19 03:45
Peer-Review Started	2025-08-19 03:46
To Make the First Decision
Return for Revision	2025-09-09 10:02
Revised	2025-09-14 13:42
Second Decision	2025-11-18 01:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-18 04:26
Articles in Press	2025-11-18 04:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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