Publication Name	World Journal of Virology
Manuscript ID	113217
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Thrombotic risk in hepatitis C: Interplay between hepatic dysfunction, viral-driven inflammation, and cardiovascular consequences
Manuscript Source	Invited Manuscript
All Author List	Mohammed Zohery, Sarah Jahangir, Hamed Carter Jenna, Shiza Sarfraz, Hadeera Ali, Muhammad Raza, Taha Rafiq, Dushyant Singh Dahiya, Vinay Jahagirdar and Hassam Ali
Funding Agency and Grant Number
Corresponding Author	Hassam Ali, MD, Division of Gastroenterology, Hepatology and Nutrition, East Carolina University/Brody School of Medicine, 2100 Statonsburg Road, Greenville, North Carolina 27858, United States. hassamali155@gmail.com
Key Words	Hepatitis C virus; Thrombotic risk; Cardiovascular disease; Endothelial dysfunction; Portal vein thrombosis; Venous thromboembolism; Systemic inflammation; Direct-acting antivirals; Coagulation imbalance; Cryoglobulinemia
Core Tip	Chronic hepatitis C virus infection is increasingly recognized as a systemic condition that promotes thrombosis through inflammation, endothelial dysfunction, and coagulation imbalance. This minireview highlights how hepatitis C contributes to portal vein thrombosis, venous thromboembolism, and cardiovascular disease. Direct-acting antiviral therapy not only clears the virus but also reduces systemic inflammation and thrombotic risk, though patients with advanced fibrosis remain vulnerable. The review emphasizes the urgent need for hepatitis C-specific thrombotic risk assessment tools and biomarker-guided strategies to improve prevention and management.
Citation	Zohery M, Jahangir S, Jenna HC, Sarfraz S, Ali H, Raza M, Rafiq T, Dahiya DS, Jahagirdar V, Ali H. Thrombotic risk in hepatitis C: Interplay between hepatic dysfunction, viral-driven inflammation, and cardiovascular consequences. World J Virol 2025; In press

Received	2025-08-19 03:36
Peer-Review Started	2025-08-19 03:36
To Make the First Decision
Return for Revision	2025-09-03 03:46
Revised	2025-09-17 03:12
Second Decision	2025-11-28 03:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-28 07:15
Articles in Press	2025-11-28 07:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3249 (online)
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