Publication Name	World Journal of Diabetes
Manuscript ID	113221
Country	Spain

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Editorial
Article Title	Farrerol and the miR-29b-3p/sirtuin 1 pathway: A mechanistic breakthrough in protecting the diabetic heart
Manuscript Source	Invited Manuscript
All Author List	Javier Donate-Correa and Carlos E Martínez-Alberto
Funding Agency and Grant Number
Corresponding Author	Javier Donate-Correa, PhD, Research Unit, University Hospital Nuestra Señora de Candelaria, Carretera del Rosario S/N, Santa Cruz de Tenerife 38010, Spain. jdonatecorrea@gmail.com
Key Words	Diabetic cardiomyopathy; Endothelial dysfunction; Ferroptosis; MicroRNA-29b-3p; Sirtuin 1; Farrerol
Core Tip	Diabetic cardiomyopathy (DCM) is a diabetes-related form of heart failure that lacks targeted therapies. Recent evidence identifies endothelial ferroptosis, an iron-dependent form of cell death, as a central driver of cardiac microvascular injury in DCM. Guo et al. demonstrate that Farrerol, a natural flavonoid, inhibits ferroptosis by downregulating microRNA-29b-3p and restoring sirtuin 1 signaling in endothelial cells, thereby improving cardiac function and reducing fibrosis in diabetic mice. Targeting endothelial ferroptosis through the microRNA-29b-3p/sirtuin 1 pathway represents a novel disease-modifying strategy for DCM.
Citation	Donate-Correa J, Martínez-Alberto CE. Farrerol and the miR-29b-3p/sirtuin 1 pathway: A mechanistic breakthrough in protecting the diabetic heart. World J Diabetes 2025; In press

Received	2025-08-20 02:44
Peer-Review Started	2025-08-27 00:34
First Decision by Editorial Office Director	2025-10-10 03:51
Return for Revision	2025-10-10 03:51
Revised	2025-10-24 13:04
Publication Fee Transferred
Second Decision by Editor	2025-12-12 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-12 07:39
Articles in Press	2025-12-12 07:39
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com