Publication Name	World Journal of Orthopedics
Manuscript ID	113228
Country	India

Category	Cell & Tissue Engineering
Manuscript Type	Review
Article Title	Advances in polymer-based hydrogel systems for adipose-derived mesenchymal stem cells toward bone regeneration
Manuscript Source	Invited Manuscript
All Author List	Nivetha Suresh, Sundaravadhanan Lekhavadhani and Nagarajan Selvamurugan
Funding Agency and Grant Number
Corresponding Author	Nagarajan Selvamurugan, PhD, Professor, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, School of Bioengineering, Kattankulathur 603203, Tamil Nādu, India. selvamun@srmist.edu.in
Key Words	Mesenchymal stem cells; Adipose-derived mesenchymal stem cells; Bone tissue engineering; Hydrogels; Bone regeneration; Polymers
Core Tip	This review highlights the critical need for advanced biomaterials in bone regeneration, emphasizing hydrogels as optimized scaffolds for adipose-derived mesenchymal stem cell delivery. The innovative aspect of this study lies in its comprehensive analysis of polymer-based hydrogels synthesis, advanced embedding techniques such as three-dimensional bioprinting, and osteoinductive modifications to enhance bone regeneration. Advancements in biomaterial engineering and stem cell technology will be essential for developing effective and clinically applicable bone tissue engineering strategies. Future research should focus on addressing scalability, regulatory challenges, and long-term safety to facilitate clinical translation.
Citation	Suresh N, Lekhavadhani S, Selvamurugan N. Advances in polymer-based hydrogel systems for adipose-derived mesenchymal stem cells toward bone regeneration. World J Orthop 2025; In press

Received	2025-08-20 05:15
Peer-Review Started	2025-08-20 05:16
To Make the First Decision
Return for Revision	2025-09-12 06:48
Revised	2025-09-25 07:05
Second Decision	2025-11-12 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-12 08:03
Articles in Press	2025-11-12 08:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com