Publication Name	World Journal of Experimental Medicine
Manuscript ID	113259
Country	Argentina

Category	Neurosciences
Manuscript Type	Review
Article Title	Renin-angiotensin system blockade attenuates brain mitochondrial dysfunction, oxidative stress, and neuroinflammation associated with hypertension, metabolic disorders, and aging
Manuscript Source	Invited Manuscript
All Author List	Sebastián García Menéndez, Felipe Inserra, Elena MV de Cavanagh, Leon Ferder and Walter Manucha
Funding Agency and Grant Number
Corresponding Author	Walter Manucha, PhD, Professor, Department of Pathology, Institute of Medicine and Experimental Biology of Cuyo, National Council for Scientific and Technological Research, National University of Cuyo, Laboratory of Basic and Translational Experimental Pharmacology, Faculty of Medical Sciences, Avenue El Libertador 80, Mendoza 5500, Argentina. wmanucha@yahoo.com.ar
Key Words	Renin-angiotensin system blockade; Oxidative stress; Central nervous system inflammation; Neurodegeneration; Hypertension; Metabolic disorders; Mitochondria; Aging
Core Tip	This study highlights renin-angiotensin system blockade as a promising strategy for preventing brain damage associated with hypertension, metabolic disorders, and aging. These conditions accelerate mitochondrial dysfunction, oxidative stress, and neuroinflammation. Our work focuses on the strategic use of angiotensin receptor blockers and ACE2 activators, demonstrating their potential to mitigate these pathological processes and offering a novel avenue for the prevention and treatment of vascular dementia and other neurodegenerative diseases.
Citation	García Menéndez S, Inserra F, de Cavanagh EMV, Ferder L, Manucha W. Renin-angiotensin system blockade attenuates brain mitochondrial dysfunction, oxidative stress, and neuroinflammation associated with hypertension, metabolic disorders, and aging. World J Exp Med 2026; In press

Received	2025-08-20 04:50
Peer-Review Started	2025-08-20 04:50
First Decision by Editorial Office Director	2025-10-13 08:46
Return for Revision	2025-10-13 08:46
Revised	2025-10-25 13:35
Publication Fee Transferred
Second Decision by Editor	2026-01-20 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-20 06:37
Articles in Press	2026-01-20 06:37
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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