Publication Name	World Journal of Gastroenterology
Manuscript ID	113299
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance
Manuscript Source	Unsolicited Manuscript
All Author List	Si-Chan Li, Shun-Zi Shao, Yu-Hang Zhang, Yu Zhou, Wen-Tao Shang, Yuan Gao, Qi-Bin He, Qing-Long Guo, Chuan-Yong Guo and Xiao-Bo Zhang
Funding Agency and Grant Number	Funding Agency Grant Number “Double First-Class University” Project of China Pharmaceutical University No. CPU2022PZQ11 Nanjing Medical Science and Technology Development Foundation No. YKK24223 Outstanding Young Teacher of Qinglan Project in Jiangsu Province
Corresponding Author	Xiao-Bo Zhang, PhD, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, No. 24 Tongjia Lane, Gulou District, Nanjing 210009, Jiangsu Province, China. xiaobozhangxibo@126.com
Key Words	Gastric carcinoma; Bortezomib; Wogonin derivative V8; Lysosome; Drug resistance; Transcription factor EB; Patient-derived organoids
Core Tip	We identified lysosomal trapping as a key mechanism of bortezomib resistance (BTZ) in gastric cancer. The novel agent V8 disrupts lysosomes, releasing BTZ to enhance proteasome targeting and induce lethal proteotoxic stress. The V8-BTZ combination shows strong synergy in cells, xenografts, and patient organoids, supporting its clinical potential for overcoming resistance.
Citation	Li SC, Shao SZ, Zhang YH, Zhou Y, Shang WT, Gao Y, He QB, Guo QL, Guo CY, Zhang XB. Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance. World J Gastroenterol 2025; In press

Received	2025-08-21 06:16
Peer-Review Started	2025-08-21 06:16
First Decision by Editorial Office Director	2025-09-09 10:24
Return for Revision	2025-09-09 10:24
Revised	2025-09-17 08:49
Publication Fee Transferred	2025-09-25 04:01
Second Decision by Editor	2025-12-23 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-23 06:06
Articles in Press	2025-12-23 06:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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