Publication Name	World Journal of Gastroenterology
Manuscript ID	113319
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Clinical implications of a dynamic nomogram for predicting sepsis in acute liver failure
Manuscript Source	Invited Manuscript
All Author List	Shi-Yan Zhang and Jin-Bao Shi
Funding Agency and Grant Number
Corresponding Author	Jin-Bao Shi, Dean, President, Professor, Department of Nephrology, Fuding Hospital, Fujian University of Traditional Chinese Medicine, No. 16 Donghu Road, Ningde 355200, Fujian Province, China. 1301803387@qq.com
Key Words	Acute liver failure; Risk prediction; Predictive model; Intensive care; Biomarkers; Dynamic nomogram
Core Tip	This letter highlights the development and validation of a dynamic nomogram for predicting sepsis risk in patients with acute liver failure. The sepsis in acute liver failure model shows robust discrimination, consistently outperforming the sequential organ failure assessment and systemic inflammatory response syndrome scores, which have been validated across both Western and Chinese intensive care unit cohorts. Future work should incorporate longitudinal clinical variables, integrate infection-related biomarkers, and pursue multicenter validation to further enhance clinical utility.
Citation	Zhang SY, Shi JB. Clinical implications of a dynamic nomogram for predicting sepsis in acute liver failure. World J Gastroenterol 2025; In press

Received	2025-08-22 08:09
Peer-Review Started	2025-08-22 08:09
First Decision by Editorial Office Director	2025-11-04 09:38
Return for Revision	2025-11-04 09:38
Revised	2025-11-14 10:13
Publication Fee Transferred
Second Decision by Editor	2025-12-22 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-22 07:06
Articles in Press	2025-12-22 07:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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