Publication Name	World Journal of Orthopedics
Manuscript ID	113320
Country	Spain

Category	Orthopedics
Manuscript Type	Basic Study
Article Title	Altered lineage commitment of bone marrow mesenchymal stem cells in idiopathic osteonecrosis of the femoral head
Manuscript Source	Unsolicited Manuscript
All Author List	Adrián Cardín-Pereda, Daniel García-Sánchez, Itziar Álvarez-Iglesias, Jennifer Cabello-Sanz and Flor M Pérez-Campo
Funding Agency and Grant Number
Corresponding Author	Flor M Pérez-Campo, Assistant Professor, PhD, Senior Researcher, Department of Molecular Biology, Instituto de Investigación Sanitaria Marqués de Valdecilla, Faculty of Medicine, University of Cantabria, Avda Cardenal Herrera Oria S/N, Santander 39011, Cantabria, Spain. f.perezcampo@unican.es
Key Words	Idiopathic osteonecrosis of the femoral head; Mesenchymal stem cells; Proliferation; Differentiation; Lineage specification; Adipogenesis; Osteogenesis
Core Tip	Directly harvested bone marrow mesenchymal stem cells from femoral heads of patients with idiopathic osteonecrosis show higher proliferation but reduced osteogenesis, increased adipogenesis and upregulated nuclear factor kappa B target genes relative to osteoarthritis controls. This hyperproliferative yet lineage-skewed phenotype offers a mechanistic link between cellular dysfunction and failed structural repair in osteonecrosis of the femoral head and supports the use of therapies that reprogramme mesenchymal stem cells fate and the bone marrow microenvironment.
Citation	Cardín-Pereda A, García-Sánchez D, Álvarez-Iglesias I, Cabello-Sanz J, Pérez-Campo FM. Altered lineage commitment of bone marrow mesenchymal stem cells in idiopathic osteonecrosis of the femoral head. World J Orthop 2025; In press

Received	2025-08-22 09:12
Peer-Review Started	2025-08-22 09:12
To Make the First Decision
Return for Revision	2025-09-08 09:54
Revised	2025-09-18 17:38
Second Decision	2025-11-06 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-06 07:30
Articles in Press	2025-11-06 07:30
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ISSN	2218-5836 (online)
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