Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	113341
Country	Saudi Arabia

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Tumor calcification and sustained complete response after chemoembolization in hepatocellular carcinoma: Two case reports and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Sultan R Alharbi
Funding Agency and Grant Number
Corresponding Author	Sultan R Alharbi, Associate Professor, MD, Interventional Radiology Unit/Department of Radiology and medical imaging, College of Medicine, King Saud University, PO Box 7805, King Abdullah Street, Riyadh 11362, Saudi Arabia. drsultan000@gmail.com
Key Words	Hepatocellular carcinoma; Transarterial chemoembolization; Drug eluting beads chemoembolization; Complete response; Remission; Tumoral calcification; Case report
Core Tip	Tumoral calcification following transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) is a rare imaging finding, and its clinical significance remains unclear. This case report describes two patients with large HCC who developed complete radiological response after drug-eluting beads TACE, followed by progressive peripheral calcification and sustained disease-free survival for 6 years. The notable association between post-TACE calcification and long-term remission raises the possibility that calcification may serve as a late imaging biomarker of effective tumor necrosis and durable treatment response.
Citation	Alharbi SR. Tumor calcification and sustained complete response after chemoembolization in hepatocellular carcinoma: Two case reports and review of literature. World J Gastrointest Oncol 2025; In press

Received	2025-08-22 10:08
Peer-Review Started	2025-08-22 10:08
To Make the First Decision
Return for Revision	2025-09-12 05:35
Revised	2025-09-22 14:04
Second Decision	2025-10-13 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-13 08:13
Articles in Press	2025-10-13 08:13
Publication Fee Transferred	2025-09-23 06:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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