Publication Name	World Journal of Cardiology
Manuscript ID	113358
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Melatonin regulates Sirt1/Nrf2/GPX4 pathway to inhibit ferroptosis and alleviate myocardial injury caused by sepsis
Manuscript Source	Unsolicited Manuscript
All Author List	Min Zeng, Qiong Li, Lin Li, Cheng-Fang Xiang and Yi-Jun Wang
Funding Agency and Grant Number	Funding Agency Grant Number 2025 Hunan Provincial Natural Science Foundation Regional Joint Fund No. 2025JJ70596
Corresponding Author	Yi-Jun Wang, Research Fellow, Department of Emergency, The First People’s Hospital of Chenzhou, No. 108 Luo Jia Jin Street, Chenzhou 423000, Hunan Province, China. wangyijun202507@163.com
Key Words	Sepsis; Myocardial injury; Echocardiography; Melatonin; Sirtuin 1; Nuclear factor erythroid 2-related factor 2; Glutathione peroxidase 4
Core Tip	Sepsis often results in myocardial injury, a major cause of death in affected patients. In this study, we demonstrated that melatonin, an endogenous hormone with antioxidant and anti-inflammatory properties, protects against sepsis-induced myocardial injury. Using both a mouse model and HL-1 cardiomyocytes, we found that melatonin improved cardiac function, reduced oxidative stress, and inhibited ferroptosis by activating the Sirt1/Nrf2/GPX4 pathway. These findings provide novel mechanistic insights and highlight the therapeutic potential of melatonin for septic myocardial injury.
Citation	Zeng M, Li Q, Li L, Xiang CF, Wang YJ. Melatonin regulates Sirt1/Nrf2/GPX4 pathway to inhibit ferroptosis and alleviate myocardial injury caused by sepsis. World J Cardiol 2025; In press

Received	2025-08-25 05:25
Peer-Review Started	2025-08-25 05:25
To Make the First Decision
Return for Revision	2025-09-18 09:26
Revised	2025-09-28 08:03
Second Decision	2025-11-28 03:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-28 06:51
Articles in Press	2025-11-28 06:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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