Publication Name	World Journal of Hepatology
Manuscript ID	113366
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Fatigue assessment in Egyptian patients with hepatitis C virus–related chronic liver disease: Single center study
Manuscript Source	Invited Manuscript
All Author List	Marwa A Tahoon, Sally W Elkhadry, Eman Abdelsameea and Reham Ashour
Funding Agency and Grant Number
Corresponding Author	Eman Abdelsameea, Professor, Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, N/A, Shebin El-Kom 32511, Egypt. eabdelsameea@liver-eg.org
Key Words	Multidimensional fatigue inventory; Chronic liver disease; Fatigue score; Hepatitis C virus; Prevalence
Core Tip	Chronic hepatitis C virus (HCV) infection is often associated with fatigue. We recruited 300 chronic HCV patients. Fatigue has been evaluated with multidimensional fatigue inventory-20 (validated tool to assess different dimensions of fatigue in this population. Significant/severe fatigue was prevalent in 27.3% of HCV patients. Decompensated liver disease, intermediate/high-risk fibrosis, < 1 year duration of last dose of antiviral treatment, and HCV infection duration were independent risk factors for fatigue. Fatigue is a widespread and complex symptom in cases with chronic HCV, closely linked to liver disease severity, antiviral treatment, and infection duration.
Citation	Tahoon MA, Elkhadry SW, Abdelsameea E, Ashour R. Fatigue assessment in Egyptian patients with hepatitis C virus–related chronic liver disease: Single center study. World J Hepatol 2026; In press

Received	2025-08-25 10:58
Peer-Review Started	2025-08-25 10:58
First Decision by Editorial Office Director	2025-09-17 08:26
Return for Revision	2025-09-17 08:26
Revised	2025-09-30 05:03
Publication Fee Transferred
Second Decision by Editor	2026-01-08 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-08 07:12
Articles in Press	2026-01-08 07:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com