Publication Name	World Journal of Gastroenterology
Manuscript ID	113381
Country	Portugal

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Dual biologic therapy in patient with refractory ulcerative colitis and comorbidities: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Andreia C Guimarães, Rocio Ferreiro-Iglesias, Cristina Calviño-Suarez, Iria Baston-Rey and Manuel Barreiro-de Acosta
Funding Agency and Grant Number
Corresponding Author	Andreia C Guimarães, MD, Department of Gastroenterology, Unidade Local de Saude de Braga, Sete Fontes, Sao Victor, Braga 4710-243, Portugal. andreiaguimaraes32@gmail.com
Key Words	Inflammatory bowel disease; Refractory ulcerative colitis; Combination therapy; Mirikizumab; Vedolizumab; Case report
Core Tip	Dual biologic therapy (DBT) is a promising treatment option for patients with refractory ulcerative colitis (UC) who have limited therapeutic alternatives. We presented the first case of a patient with extensive UC treated with mirikizumab and vedolizumab due to contraindications to tumor necrosis factor and Janus kinase inhibitors. The combination of mirikizumab and vedolizumab led to sustained clinical and biochemical remission without adverse events. Our case highlighted the therapeutic potential and safety of DBT in selected patients, reinforcing the need for individualized treatment strategies in complex clinical scenarios.
Citation	Guimarães AC, Ferreiro-Iglesias R, Calviño-Suarez C, Baston-Rey I, Barreiro-de Acosta M. Dual biologic therapy in patient with refractory ulcerative colitis and comorbidities: A case report. World J Gastroenterol 2025; In press

Received	2025-08-25 12:43
Peer-Review Started	2025-08-25 12:43
To Make the First Decision
Return for Revision	2025-09-17 08:50
Revised	2025-09-27 19:22
Second Decision	2025-11-04 02:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-04 08:20
Articles in Press	2025-11-04 08:20
Publication Fee Transferred	2025-10-10 11:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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