Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	113431
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Folate receptor-positive circulating tumor cells might function as potential biomarkers for hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Zun-Yi Zhang, Mi Zhou, Jun-Jie Liu and Wei Zhang
Funding Agency and Grant Number
Corresponding Author	Wei Zhang, Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Road, Wuhan 430030, Hubei Province, China. weizhangtjh@hust.edu.cn
Key Words	Folate receptor-circulating tumor cells; Hepatocellular carcinoma; Potential biomarker; Vascular invasion; Recurrence
Core Tip	Ligand-target polymerase chain reaction is a sensitive tool for quantifying folate receptor (FR)-positive circulating tumor cells (CTCs) in hepatocellular carcinoma (HCC) patients. FR + CTCs counts were correlated with macrovascular invasion, tumor size, tumor number, extrahepatic tumor stage and disease-free survival time after surgery in HCC patients. These findings could provide new insights for stratifying HCC patients and predicting the recurrence of HCC by quantifying FR + CTCs.
Citation	Zhang ZY, Zhou M, Liu JJ, Zhang W. Folate receptor-positive circulating tumor cells might function as potential biomarkers for hepatocellular carcinoma. World J Gastrointest Oncol 2025; In press

Received	2025-08-26 01:28
Peer-Review Started	2025-08-26 01:28
To Make the First Decision
Return for Revision	2025-09-01 08:25
Revised	2025-09-14 02:18
Second Decision	2025-10-21 02:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-21 08:05
Articles in Press	2025-10-21 08:05
Publication Fee Transferred	2025-09-15 02:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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