Publication Name	World Journal of Gastroenterology
Manuscript ID	113432
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Beyond rheumatology: Reconsidering methotrexate for Crohn’s disease in the biologic era
Manuscript Source	Invited Manuscript
All Author List	Jun-Young Seo and Jun Hwan Yoo
Funding Agency and Grant Number
Corresponding Author	Jun Hwan Yoo, Associate Professor, MD, PhD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam-si 13496, South Korea. jhyoo@cha.ac.kr
Key Words	Methotrexate; Crohn’s disease; Biologics; Immunosuppressants; Clinical practice
Core Tip	Methotrexate remains underutilized in Crohn’s disease management despite its favorable safety and established efficacy. The nationwide French survey by Bonnaud et al has shown that barriers are less about evidence than about clinical inertia and limited familiarity. Reconsidering methotrexate as a frontline immunomodulator, particularly in the biologic era, may provide a cost-effective and individualized therapeutic strategy.
Citation	Seo JY, Yoo JH. Beyond rheumatology: Reconsidering methotrexate for Crohn’s disease in the biologic era. World J Gastroenterol 2025; In press

Received	2025-08-26 02:54
Peer-Review Started	2025-08-26 02:54
To Make the First Decision
Return for Revision	2025-09-28 10:48
Revised	2025-10-09 14:21
Second Decision	2025-11-24 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-24 08:03
Articles in Press	2025-11-24 08:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com