Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	113439
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Relationship between the appendix and ulcerative colitis: A new discovery
Manuscript Source	Unsolicited Manuscript
All Author List	Xu-Jia Wu, Reng-Yun Xiang, Pan Gong, Qian Chen and Xue-Feng Li
Funding Agency and Grant Number
Corresponding Author	Xue-Feng Li, Chief Physician, PhD, Professor, Department of Gastroenterology, The First Affiliated Hospital of Jishou University, No. 108 Jian Xin Road, Jishou 416000, Hunan Province, China. longs9877@aliyun.com
Key Words	Appendix; Ulcerative colitis; Inflammation; Immunity; Gut microbiota
Core Tip	Investigating the relationship between the appendix and ulcerative colitis (UC) is crucial for understanding of UC pathogenesis. Appendectomy is superior to standard medical therapy alone in maintaining remission in patients with UC, suggesting that the appendix is a priming site for UC. Other studies have shown that appendectomy increases the risk of colorectal resection and colorectal cancer in UC. Therefore, further research is needed to establish whether the connection is clinically relevant. This review highlights the need for ongoing research to elucidate the complex relationship between the appendix and UC, providing valuable insights with significant promise for developing novel therapeutics.
Citation	Wu XJ, Xiang RY, Gong P, Chen Q, Li XF. Relationship between the appendix and ulcerative colitis: A new discovery. World J Gastrointest Endosc 2025; In press

Received	2025-08-26 01:18
Peer-Review Started	2025-08-26 01:18
First Decision by Editorial Office Director	2025-09-20 02:26
Return for Revision	2025-09-21 13:41
Revised	2025-10-22 12:13
Publication Fee Transferred	2025-10-23 06:06
Second Decision by Editor	2025-12-05 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-05 08:52
Articles in Press	2025-12-05 08:52
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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