Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	113440
Country	China

Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Efficacy and safety of immune checkpoint inhibitors plus chemotherapy in esophageal cancer patients with liver metastases
Manuscript Source	Unsolicited Manuscript
All Author List	En-Hui Dai, Shu-Hao Que, Huan Xu, Guo-Qiang Zhong, Zhen Zhang, Xu Liang, Shu-Wei Zhai, Yue-Tong Li, Jing-Jing Wang and Wei Feng
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82303672 Zhejiang Provincial Health Commission and Zhejiang Provincial Administration of Traditional Chinese Medicine through the Targeted Project for Medical and Health Research 2025ZL017 China Primary Health Care Foundation ZLMY20240311001ZJ
Corresponding Author	Wei Feng, MD, Department of Thoracic Radiotherapy, Zhejiang Cancer Hospital, No. 1 Banshan East Road, Gongshu District, Hangzhou 310022, Zhejiang Province, China. fengwei@zjcc.org.cn
Key Words	Esophageal cancer; Liver metastasis; Chemotherapy; Immunotherapy; Local liver-directed therapy
Core Tip	Although chemoimmunotherapy is the standard first-line treatment for metastatic esophageal cancer, its efficacy in the subgroup with liver metastases remains poorly characterized. This study demonstrated that chemoimmunotherapy significantly improved overall survival in this population, with a manageable safety profile. Key prognostic factors were identified, and the addition of local therapy to liver metastases may provide a rational approach to further optimize treatment outcomes.
Citation	Dai EH, Que SH, Xu H, Zhong GQ, Zhang Z, Liang X, Zhai SW, Li YT, Wang JJ, Feng W. Efficacy and safety of immune checkpoint inhibitors plus chemotherapy in esophageal cancer patients with liver metastases. World J Gastrointest Oncol 2025; In press

Received	2025-08-27 17:07
Peer-Review Started	2025-08-27 17:07
To Make the First Decision
Return for Revision	2025-09-18 09:03
Revised	2025-10-11 03:58
Second Decision	2025-11-18 01:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-18 08:19
Articles in Press	2025-11-18 08:19
Publication Fee Transferred	2025-10-13 09:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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