Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	113444
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Mechanism of Xiaozhiling injection in the treatment of internal hemorrhoids based on changes in perianal blood flow and rectal submucosal fibers
Manuscript Source	Unsolicited Manuscript
All Author List	Shu-Yan Huang, Wei-Gan Lin, Hong Lan, Zhen-Guo Xu, Xia-Xia Zheng, Xian-Bao Liu, You-Min Cheng, Zuan-Fang Li and Min-Hui Ke
Funding Agency and Grant Number
Corresponding Author	Min-Hui Ke, Department of Proctology, The Second People’s Hospital Affiliated with Fujian University of Traditional Chinese Medicine, No. 282 Wusi Road, Gulou District, Fuzhou 350003, Fujian Province, China. 48330132@qq.com
Key Words	Rat internal hemorrhoid model; Xiaozhiling injection; Submucosal thickness; Fibrous tissue; Perianal blood flow
Core Tip	Xiaozhiling injection exerts its prominent therapeutic efficacy by potently stimulating the proliferation of collagen fibres within the submucosal layer of the hemorrhoidal tissue, which in turn remodels the originally loose and disorganized connective tissue into a compact, well-aligned structure. This targeted tissue-modulating mechanism not only alleviates the key symptoms of internal haemorrhoids but also holds great promise for paving a novel, minimally invasive therapeutic avenue for this prevalent anorectal disorder.
Citation	Huang SY, Lin WG, Lan H, Xu ZG, Zheng XX, Liu XB, Cheng YM, Li ZF, Ke MH. Mechanism of Xiaozhiling injection in the treatment of internal hemorrhoids based on changes in perianal blood flow and rectal submucosal fibers. World J Gastrointest Pharmacol Ther 2025; In press

Received	2025-08-26 01:33
Peer-Review Started	2025-08-26 01:33
First Decision by Editorial Office Director	2025-09-12 06:31
Return for Revision	2025-09-12 15:08
Revised	2025-09-15 14:48
Publication Fee Transferred	2025-09-18 07:24
Second Decision by Editor	2025-12-19 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-19 10:31
Articles in Press	2025-12-19 10:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com