Publication Name	World Journal of Stem Cells
Manuscript ID	113456
Country	China

Category	Dermatology
Manuscript Type	Letter to the Editor
Article Title	Advancing human adipose-derived mesenchymal stem cell-derived exosomes for androgenetic alopecia: Appraisal and methodological recommendations
Manuscript Source	Unsolicited Manuscript
All Author List	Yu Jiang, Wen-Jun Huang and Rui Zhou
Funding Agency and Grant Number
Corresponding Author	Rui Zhou, Associate Professor, PhD, Shaanxi Institute for Pediatric Diseases, Affiliated Children’s Hospital of Xi’an Jiaotong University, No. 69 West Juyuan Lane, Lianhu District, Xi’an 710003, Shaanxi Province, China. zhouhuaxizhu@126.com
Key Words	Androgenetic alopecia; Extracellular vesicles; Human adipose-derived mesenchymal stem cell-derived exosomes; CDC42; Wnt/β-catenin signaling; Quality control; Dermal papilla cells
Core Tip	Key challenges for translating human adipose-derived mesenchymal stem cell-derived exosomes in androgenetic alopecia include: Incomplete exosome marker information; lack of standardized reporting for particle counts and protein content; absence of direct CDC42 function validation; limited depth in Wnt/β-catenin pathway analysis; insufficient biochemical data in animal models; undefined microneedle delivery parameters; limited safety profiling; and lack of integrated quality control and potency release criteria.
Citation	Jiang Y, Huang WJ, Zhou R. Advancing human adipose-derived mesenchymal stem cell-derived exosomes for androgenetic alopecia: Appraisal and methodological recommendations. World J Stem Cells 2025; In press

Received	2025-09-03 06:06
Peer-Review Started	2025-09-03 06:06
To Make the First Decision
Return for Revision	2025-09-16 09:17
Revised	2025-09-30 12:33
Second Decision	2025-11-21 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-21 10:05
Articles in Press	2025-11-21 10:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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