Publication Name	World Journal of Clinical Oncology
Manuscript ID	113463
Country	Israel

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Patients’ perception of proton pump inhibitors use and their risks
Manuscript Source	Unsolicited Manuscript
All Author List	Ibrahim O Sawaied, Abraham O Samson and Efrat Golan
Funding Agency and Grant Number
Corresponding Author	Ibrahim O Sawaied, Azrieli Faculty of Medicine, Bar Ilan University, Henrietta Szold St 8, Safed 2170000, Israel. ibomsa13@gmail.com
Key Words	Proton pump inhibitors; Gastric cancer; Patient awareness; Adverse effects; Clinical practice; Deprescribing
Core Tip	This study is among the largest cross-sectional surveys of proton pump inhibitor users, involving 3000 patients across Israel. We found that most patients are unaware of the risks associated with long-term proton pump inhibitor therapy, including the potential link to gastric cancer. Despite lansoprazole showing a safer profile and greater improvements in quality of life, it remains underutilized compared with omeprazole and esomeprazole. Family support emerged as a protective factor, encouraging deprescribing attempts and improving patient outcomes. These findings highlight the need for better patient education, risk communication, and alignment of prescribing practices with current clinical evidence.
Citation	Sawaid IO, Samson AO, Golan E Patients’ perception of proton pump inhibitors use and their risks. 2025; World J Clin Oncol In press

Received	2025-08-26 04:50
Peer-Review Started	2025-08-26 04:50
First Decision by Editorial Office Director	2025-09-04 07:19
Return for Revision	2025-09-04 07:19
Revised	2025-09-15 15:19
Publication Fee Transferred	2025-11-20 11:44
Second Decision by Editor	2025-12-23 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-23 07:55
Articles in Press	2025-12-23 07:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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