Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	113476
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Association between type 2 diabetes mellitus and colorectal adenoma: A retrospective study with insights into Wnt/β-Catenin/TCF7L2 pathway activation
Manuscript Source	Unsolicited Manuscript
All Author List	Shu-Yan Gui, Ruo-Xi Tang, Xing Huang, Guo-Qiang Yang and Jing Yang
Funding Agency and Grant Number	Funding Agency Grant Number the Outstanding Team Fund of the Nanshan District Health System - Shenzhen City NSZD2025004 the Major Science and Technology Plan Project of Nanshan District - Shenzhen City NSZD2025016 the Major Science and Technology Plan Project of Nanshan District - Shenzhen City NSZD2024017
Corresponding Author	Jing Yang, Chief Physician, PhD, Department of Endocrinology, Shenzhen Nanshan People’s Hospital, Affiliated Nanshan Hospital of Shenzhen University, No. 89 Taoyuan Road, Nanshan District, Shenzhen 518052, Guangdong Province, China. yangjing.med@email.szu.edu.cn
Key Words	Type 2 diabetes; Colorectal adenoma; Transcription factor 7 like 2; Wnt signaling; β-catenin
Core Tip	This small-scale retrospective cohort study confirmed that type 2 diabetes mellitus is a significant independent risk factor for colorectal adenomas. The results of this study indicate that Wnt/β-catenin/transcription factor 7 like 2 pathway activation is considered a common molecular pathological basis in the association of type 2 diabetes mellitus with colorectal adenoma occurrence and development. The results of this study support the inclusion of colonoscopy screening in the routine clinical management pathway for patients with type 2 diabetes mellitus.
Citation	Gui SY, Tang RX, Huang X, Yang GQ, Yang J. Association between type 2 diabetes mellitus and colorectal adenoma: A retrospective study with insights into Wnt/β-Catenin/TCF7L2 pathway activation. World J Gastrointest Surg 2025; In press

Received	2025-10-14 09:14
Peer-Review Started	2025-10-14 09:14
First Decision by Editorial Office Director	2025-10-29 08:04
Return for Revision	2025-10-29 08:04
Revised	2025-11-17 07:19
Publication Fee Transferred
Second Decision by Editor	2025-12-22 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-22 03:29
Articles in Press	2025-12-22 03:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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