Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	113478
Country	Egypt

Category	Pediatrics
Manuscript Type	Prospective Study
Article Title	Neonatal cholestasis is associated with cytochrome P450 1A2 detoxification defect: A single center pilot study
Manuscript Source	Invited Manuscript
All Author List	Magd A Kotb, Manal M Wilson, Amani N Shafik, Noura A Ahmed, Veronia F Fahim, Nabil A Lotfi and Yasmin MR Eissawy
Funding Agency and Grant Number
Corresponding Author	Veronia F Fahim, PhD, Department of Medical Pharmacology, Faculty of Medicine, Cairo University, Kasr El Ainy St., Kasr-Alainy, El Manial, Cairo 11956, Egypt. veronia.fawzy@kasralainy.edu.eg
Key Words	Cytochrome P450 1A2; Neonatal cholestasis; Biliary atresia; Detoxification; Aflatoxins
Core Tip	This study investigated cytochrome P450 1A2 (CYP1A2) detoxification enzyme levels in neonates with confirmed biliary atresia (BA), neonatal hepatitis and healthy infants. Significantly low serum CYP1A2 was frequent among BA and neonatal hepatitis patients compared to the control group. The synergism of null glutathione S-transferase and low serum CYP1A2 in BA; the Kotb disease maybe an additional factor that compromises the aflatoxins detoxification with subsequent acceleration of the progressive inflammatory adhesions and obliterative cholangiopathy early in life. Reduced CYP1A2 seems to be an inherent susceptibility to hepatitis in the neonatal period and may alter drugs’ pharmacokinetics. Careful consideration to drug dosing and toxicity risk should be given.
Citation	Kotb MA, Wilson MM, Shafik AN, Ahmed NA, Fahim VF, Lotfi NA, Eissawy YMR. Neonatal cholestasis is associated with cytochrome P450 1A2 detoxification defect: A single center pilot study. World J Clin Pediatr 2025; In press

Received	2025-08-27 23:38
Peer-Review Started	2025-08-27 23:38
First Decision by Editorial Office Director	2025-09-17 08:22
Return for Revision	2025-09-17 08:22
Revised	2025-09-28 10:33
Publication Fee Transferred
Second Decision by Editor	2025-12-15 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-15 08:26
Articles in Press	2025-12-15 08:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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