Publication Name	World Journal of Gastroenterology
Manuscript ID	113492
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Machine learning-based prediction models for liver-related events in patients with hepatitis B-related cirrhosis and clinically significant portal hypertension
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Qiu Li, Zhuo-Jun Li, Yong-Qi Li, Ying Feng and Xian-Bo Wang
Funding Agency and Grant Number	Funding Agency Grant Number the High-level Chinese Medicine Key Discipline Construction Project zyyzdxk-2023005 Capital’s Funds for Health Improvement and Research 2024-1-2173 National Natural Science Foundation of China 82474419 National Natural Science Foundation of China 82474426 Beijing Municipal Natural Science Foundation 7232272 Beijing Traditional Chinese Medicine Technology Development Fund Project BJZYZD-2023-12
Corresponding Author	Xian-Bo Wang, Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, No. 8 Jing Shun East Street, Chaoyang District, Beijing 100015, China. wangxb@ccmu.edu.cn
Key Words	Hepatitis B; Liver cirrhosis; Clinically significant portal hypertension; Machine learning; Liver-related events; Prediction model
Core Tip	This study developed and validated machine learning models to predict liver-related events in patients with compensated hepatitis B virus-related cirrhosis and clinically significant portal hypertension. Among five models, extreme gradient boosting and random forest achieved the best accuracy and clinical utility. The liver stiffness measurement-to-platelet ratio (LPR) emerged as the most influential predictor, interacting with hemoglobin, international normalized ratio, and spleen thickness. These findings highlight machine learning based on LPR as a robust noninvasive method and provide a novel, interpretable tool for early risk stratification and personalized management in compensated cirrhosis.
Citation	Li YQ, Li ZJ, Li YQ, Feng Y, Wang XB. Machine learning-based prediction models for liver-related events in patients with hepatitis B-related cirrhosis and clinically significant portal hypertension. World J Gastroenterol 2025; In press

Received	2025-08-27 23:13
Peer-Review Started	2025-08-27 23:13
First Decision by Editorial Office Director	2025-11-04 09:38
Return for Revision	2025-11-04 09:38
Revised	2025-11-22 15:46
Publication Fee Transferred
Second Decision by Editor	2025-12-17 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-17 13:53
Articles in Press	2025-12-17 13:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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