Publication Name	World Journal of Gastroenterology
Manuscript ID	113505
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Determination of correlation of clearance with clinical outcomes for inflammatory bowel disease
Manuscript Source	Unsolicited Manuscript
All Author List	Diane R Mould, Maximillian Kutschera, Christian Primas, Sieglinde Reinisch, Gottfried Novacek, Cornelia Lichtenberger, Thierry Dervieux, Yunju Bae, Sun Hee Lee, Joon Ho Lee and Walter Reinisch
Funding Agency and Grant Number
Corresponding Author	Diane R Mould, PhD, Projections Research Inc, 535 Springview Lane, Phoenixville, PA 19460, United States. drmould@pri-home.net
Key Words	Antidrug antibodies; Bayesian model-guided dosing; Clearance; Inflammatory bowel disease; Infliximab; Pharmacokinetics; Therapeutic drug monitoring
Core Tip	There have been several evaluations of the relationship between therapeutic antibody clearance and outcomes. Data from a large study in patients administered infliximab at labeled dose were used to assess probability of antidrug antibodies, C-reactive protein normalization, and mucosal healing based on baseline clearance. A compassionate use study further evaluated these correlations, and clearance often decreased from baseline due to individualized dosing, suggesting improvements in the probability of all outcomes. While this study is small, the results are encouraging and suggest that further research on the use of clearance as a therapeutic endpoint is warranted in this area.
Citation	Mould DR, Kutschera M, Primas C, Reinisch S, Novacek G, Lichtenberger C, Dervieux T, Bae Y, Lee SH, Lee JH, Reinisch W. Determination of correlation of clearance with clinical outcomes for inflammatory bowel disease. World J Gastroenterol 2025; In press

Received	2025-08-28 01:56
Peer-Review Started	2025-08-28 01:57
First Decision by Editorial Office Director	2025-09-04 10:47
Return for Revision	2025-09-04 10:47
Revised	2025-09-18 21:09
Publication Fee Transferred	2025-09-26 15:48
Second Decision by Editor	2025-12-15 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-15 09:43
Articles in Press	2025-12-15 09:43
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Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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