Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	113518
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Patterns and risk factors of early recurrence after radical resection for intrahepatic cholangiocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Chen-Yang Zhou, Jing-Yuan Chen, Dan Wang, Shu Zhu and Hong-Chang Luo
Funding Agency and Grant Number
Corresponding Author	Hong-Chang Luo, Associate Chief Physician, MD, Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Qiaokou District, Wuhan 430030, Hubei Province, China. m18730873442@163.com
Key Words	Intrahepatic cholangiocarcinoma; Early recurrence; Radical resection; Risk factors; Prognosis; Survival
Core Tip	Intrahepatic cholangiocarcinoma demonstrates substantial susceptibility to early postoperative recurrence, which profoundly compromises clinical prognosis. Within this extensive retrospective investigation involving 386 participants, 46.1% manifested early disease recurrence during the initial 12 postoperative months, exhibiting a median overall survival duration of merely 18.5 months. Six autonomous predictive indicators were determined: Neoplasm diameter exceeding 5 cm, multiple lesions, metastatic lymph node involvement, microscopic vascular invasion, carbohydrate antigen 19-9 exceeding 200 U/mL, and R1 resection status. An innovative risk assessment framework successfully stratified individuals into low-, intermediate-, and high-risk categories, facilitating personalized surveillance protocols and adjuvant treatment strategies to optimize postoperative outcomes in intrahepatic cholangiocarcinoma management.
Citation	Zhou CY, Chen JY, Wang D, Zhu S, Luo HC. Patterns and risk factors of early recurrence after radical resection for intrahepatic cholangiocarcinoma. World J Gastrointest Surg 2025; In press

Received	2025-09-16 09:31
Peer-Review Started	2025-09-16 09:31
To Make the First Decision
Return for Revision	2025-10-10 02:29
Revised	2025-10-20 14:57
Second Decision	2025-11-28 03:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-28 05:58
Articles in Press	2025-11-28 05:58
Publication Fee Transferred	2025-10-22 03:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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