Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	113524
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Exosomal miR-191 promotes colorectal cancer progression by inducing M2 macrophage polarization and inhibiting ferroptosis
Manuscript Source	Unsolicited Manuscript
All Author List	Qing-Yun Zhao and Shou-Jiang Wei
Funding Agency and Grant Number
Corresponding Author	Shou-Jiang Wei, Professor, Department of Gastrointestinal Surgery, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, No. 1 Maoyuan Road, Shunqing District, Nanchong 637000, Sichuan Province, China. nsmcwsj@163.com
Key Words	Colorectal cancer; MiR-191; Exosome; Macrophages; Ferroptosis; M2 polarization
Core Tip	We successfully isolated exosomes from colorectal cancer (CRC) cells. Inhibition of miR-191 in CRC cells suppressed M2 polarization of macrophages. After coculture of macrophages, inhibition of miR-191 induced reactive oxygen species production, ferroptosis, and apoptosis of CRC cells. Silencing of exosomal miR-191 from CRC cells prevented M2 polarization of macrophages, and weakened CRC development by inducing ferroptosis in macrophages. Exosomal miR-191 also accelerated cancer progression in CRC nude mice by promoting M2 polarization of macrophages.
Citation	Zhao QY, Wei SJ. Exosomal miR-191 promotes colorectal cancer progression by inducing M2 macrophage polarization and inhibiting ferroptosis. World J Gastrointest Oncol 2025; In press

Received	2025-08-28 00:29
Peer-Review Started	2025-08-28 00:29
To Make the First Decision
Return for Revision	2025-09-16 07:48
Revised	2025-09-17 15:04
Second Decision	2025-11-06 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-06 08:43
Articles in Press	2025-11-06 08:43
Publication Fee Transferred	2025-09-21 06:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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