Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	113525
Country	China

Category	Anesthesiology
Manuscript Type	Retrospective Study
Article Title	Impact of dexmedetomidine preconditioning on analgesic and postoperative recovery in elderly patients undergoing laparoscopic cholecystectomy
Manuscript Source	Unsolicited Manuscript
All Author List	Min Chen, Fang-Ci Chen, Qin Pan and Zhao-Hui Liu
Funding Agency and Grant Number
Corresponding Author	Zhao-Hui Liu, Associate Chief Physician, Department of Colorectal Surgery, The First People's Hospital of Linping District Hangzhou City, No. 369 Yingbin Road, Nanyuan Subdistrict, Hangzhou 311199, Zhejiang Province, China. 15397152776@139.com
Key Words	Dexmedetomidine; Preconditioning anesthesia; Laparoscopic cholecystectomy; Elderly patients; Postoperative pain; Recovery
Core Tip	This study demonstrates that administering a loading dose of dexmedetomidine (DEX) as a pre-treatment strategy before anesthesia induction offers notable benefits for elderly patients undergoing laparoscopic cholecystectomy. Compared to the routine use of DEX solely during surgery, pre-treatment with DEX enhanced postoperative analgesia, reduced oxidative stress and inflammation, accelerated recovery of gastrointestinal and cognitive functions, and lowered the incidence of agitation without increasing intraoperative hemodynamic risks. These findings highlight the critical importance of the timing of DEX administration and suggest a promising optimized anesthesia approach to promote recovery in elderly surgical patients.
Citation	Chen M, Chen FC, Pan Q, Liu ZH. Impact of dexmedetomidine preconditioning on analgesic and postoperative recovery in elderly patients undergoing laparoscopic cholecystectomy. World J Gastrointest Surg 2025; In press

Received	2025-09-12 08:26
Peer-Review Started	2025-09-12 08:26
First Decision by Editorial Office Director	2025-10-10 02:27
Return for Revision	2025-10-10 02:27
Revised	2025-10-24 08:00
Publication Fee Transferred	2025-10-28 06:53
Second Decision by Editor	2025-12-08 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-08 04:29
Articles in Press	2025-12-08 04:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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