Publication Name	World Journal of Clinical Oncology
Manuscript ID	113527
Country	China

Category	Oncology
Manuscript Type	Evidence Review
Article Title	Role of lactylation in tumorigenesis: Analysis based on the ten hallmarks of cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Jin-Hao Chen, Jiang-Qiuchen Wu and Cun-Ming Lv
Funding Agency and Grant Number
Corresponding Author	Cun-Ming Lv, Academic Fellow, College of Basic Medical Sciences, China Three Gorges University, No. 8 Daxue Road, Yichang 443002, Hubei Province, China. lvcunming2003@163.com
Key Words	Lactylation; Tumor microenvironment; Metabolic reprogramming; Immune evasion; Signal transduction
Core Tip	Lactylation links metabolism to gene expression in cancer, serving as a critical epigenetic regulatory mechanism. Lactylation regulates key cancer hallmarks, including uncontrolled growth and invasive metastasis. Targeting lactylation-related enzymes can effectively enhance and improve current cancer therapies. Lactylation markers may serve as reliable cancer biomarkers for early diagnosis and prognosis. Understanding lactylation can lead to personalized cancer treatments.
Citation	Chen JH, Wu JQ, Lv C. Role of lactylation in tumorigenesis: Analysis based on the ten hallmarks of cancer. World J Clin Oncol 2026; In press

Received	2025-08-28 00:12
Peer-Review Started	2025-08-28 00:12
First Decision by Editorial Office Director	2025-09-16 09:49
Return for Revision	2025-09-16 09:49
Revised	2025-09-18 17:16
Publication Fee Transferred	2025-10-16 16:08
Second Decision by Editor	2026-03-10 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-10 10:13
Articles in Press	2026-03-10 10:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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