Publication Name	World Journal of Gastroenterology
Manuscript ID	113528
Country	China

Category	Health Care Sciences & Services
Manuscript Type	Letter to the Editor
Article Title	Additional considerations on vonoprazan triple therapy for Helicobacter pylori eradication: Implementation challenges and clinical perspectives
Manuscript Source	Unsolicited Manuscript
All Author List	Chu-Ying Sun and Ming-Xian Chen
Funding Agency and Grant Number
Corresponding Author	Ming-Xian Chen, Chief Physician, MD, Professor, Department of Gastroenterology, Tongde Hospital of Zhejiang Province, No. 234 Gucui Road, Hangzhou 310012, Zhejiang Province, China. chenmingxian2005@126.com
Key Words	Helicobacter pylori; Vonoprazan; Multicenter trial; Regional differences; Clinical implementation
Core Tip	Han et al’s multicenter trial demonstrates vonoprazan triple therapy’s superior efficacy over standard bismuth quadruple therapy for Helicobacter pylori eradication in China, successful nationwide implementation faces critical challenges. Key barriers include limited drug accessibility in primary healthcare settings, higher costs compared to traditional therapies, and significant regional variations in antibiotic resistance patterns across China’s diverse population. The study’s single-province design cannot fully represent national applicability. Addressing these implementation gaps through comprehensive health system research, cost-effectiveness analyses, and multi-regional validation studies is essential for translating these promising clinical findings into improved patient outcomes across China’s heterogeneous healthcare landscape.
Citation	Sun CY, Chen MX. Additional considerations on vonoprazan triple therapy for Helicobacter pylori eradication: Implementation challenges and clinical perspectives. World J Gastroenterol 2025; In press

Received	2025-08-27 23:10
Peer-Review Started	2025-08-27 23:11
To Make the First Decision
Return for Revision	2025-09-20 02:27
Revised	2025-10-02 20:34
Second Decision	2025-11-04 02:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-04 08:39
Articles in Press	2025-11-04 08:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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