Publication Name	World Journal of Gastroenterology
Manuscript ID	113529
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Synergistic antitumor effect of oroxylin A and donafenib in hepatocellular carcinoma through tumor protein p53 signaling pathway activation
Manuscript Source	Unsolicited Manuscript
All Author List	Mei-Yuan Zhang, Rui-Qian Sun, Qi Min, Yu-Qi Zhu, Shu-Kui Qin and Qing-Long Guo
Funding Agency and Grant Number
Corresponding Author	Mei-Yuan Zhang, Intensive Care Unit, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine/Shanghai Key Laboratory of Embryo Original Disease, Shanghai Municipal Key Clinical Specialty, No. 1567 Jinqian Road, Fengxian District, Shanghai 201499, China. zhangmeiyuan1972@163.com
Key Words	Hepatocellular carcinoma; Oroxylin A; Donafenib; Combination therapy; Xenograft tumor; TP53 signaling pathway
Core Tip	This study demonstrates that the combination of oroxylin A and donafenib exerts a potent synergistic antitumor effect against hepatocellular carcinoma in vitro and in vivo. Mechanistically, this synergy is achieved through the convergent activation of the tumor-suppressive tumor protein p53 signaling pathway. This work provides a novel and effective therapeutic strategy for hepatocellular carcinoma.
Citation	Zhang MY, Sun RQ, Min Q, Zhu YQ, Qin SK, Guo QL. Synergistic antitumor effect of oroxylin A and donafenib in hepatocellular carcinoma through tumor protein p53 signaling pathway activation. World J Gastroenterol 2025; In press

Received	2025-09-16 09:21
Peer-Review Started	2025-09-16 09:21
First Decision by Editorial Office Director	2025-10-13 09:07
Return for Revision	2025-10-13 09:07
Revised	2025-10-31 06:43
Publication Fee Transferred	2025-11-04 03:31
Second Decision by Editor	2025-12-11 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-11 11:12
Articles in Press	2025-12-11 11:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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