Publication Name	World Journal of Gastroenterology
Manuscript ID	113550
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Capecitabine maintenance after radiofrequency ablation: A preventive strategy for lung oligometastases from colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Francesco Giangregorio
Funding Agency and Grant Number
Corresponding Author	Francesco Giangregorio, Associate Professor, Chief Physician, Director, Department of Internal Medicine, Castel San Giovanni Hospital, Viale II Giugno 1, Castel San Giovanni, Piacenza 29015, Emilia-Romagna, Italy. f.giangregorio67@gmail.com
Key Words	Colorectal cancer; Lung oligometastases; Radiofrequency ablation; Capecitabine; Maintenance therapy; Recurrence prevention
Core Tip	Preventing the recurrence of lung oligometastases from colorectal cancer after local therapy is crucial. Recent evidence demonstrated that capecitabine maintenance after radiofrequency ablation significantly increased 5-year overall survival and reduced 5-year local tumor progression rates compared with radiofrequency ablation alone. This synergistic approach proactively targets micrometastatic disease. Despite the retrospective nature of the study, its robust results support the confirmation of systemic maintenance with local ablation in prospective randomized controlled trials.
Citation	Giangregorio F. Capecitabine maintenance after radiofrequency ablation: A preventive strategy for lung oligometastases from colorectal cancer. World J Gastroenterol 2025; In press

Received	2025-08-28 00:03
Peer-Review Started	2025-08-28 00:03
To Make the First Decision
Return for Revision	2025-09-28 10:49
Revised	2025-10-11 22:10
Second Decision	2025-11-06 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-06 06:46
Articles in Press	2025-11-06 06:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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