Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	113553
Country	Mexico

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Tumor microenvironment-driven microRNA dysregulation: Key interactions in colorectal cancer progression
Manuscript Source	Invited Manuscript
All Author List	Adriana G Quiroz-Reyes, Paulina Delgado-Gonzalez, Jose Francisco Islas, Veronica L Loaiza-Gutierrez, Michelle G Santoyo-Suarez, Juan A Garcia-Loredo, Carlos A Gonzalez-Villarreal, Fernanda Ramirez-Fernandez and Elsa N Garza-Treviño
Funding Agency and Grant Number
Corresponding Author	Elsa N Garza-Treviño, Affiliate Associate Professor, Associate Professor, Department of Biochemistry and Molecular Medicine, Universidad Autonoma de Nuevo Leon, Av. Francisco I Madero Pte. s/n y Calle Dr. Eduardo Aguirre Pequeño. Colonia Mitras Centro, Monterrey 64460, Nuevo Leon, Mexico. elsa.garzatr@uanl.edu.mx
Key Words	Cancer progression; MicroRNAs; Colorectal cancer; Tumor microenvironment; Therapeutic response
Core Tip	MicroRNAs are crucial regulators of colorectal cancer progression, influencing tumor development, therapeutic response, and serving as potential biomarkers or therapeutic targets. Their expression is strongly shaped by the dynamic interaction between tumor cells and the tumor microenvironment. This comprehensive review summarizes the key microRNAs implicated in tumor progression and discusses the main therapeutic targets, highlighting current knowledge and strategies designed to modulate their expression and enhance treatment response.
Citation	Quiroz-Reyes AG, Delgado-Gonzalez P, Islas JF, Loaiza-Gutierrez VL, Santoyo-Suarez MG, Garcia-Loredo JA, Gonzalez-Villarreal CA, Ramirez-Fernandez F, Garza-Treviño EN. Tumor microenvironment-driven microRNA dysregulation: Key interactions in colorectal cancer progression. World J Gastrointest Oncol 2025; In press

Received	2025-09-02 04:47
Peer-Review Started	2025-09-02 04:48
To Make the First Decision
Return for Revision	2025-09-09 09:27
Revised	2025-09-30 03:01
Second Decision	2025-11-18 01:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-18 08:29
Articles in Press	2025-11-18 08:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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