Publication Name	World Journal of Nephrology
Manuscript ID	113599
Country	United States

Category	Health Care Sciences & Services
Manuscript Type	Retrospective Cohort Study
Article Title	Long-term patiromer adherence and renin-angiotensin aldosterone system inhibitor utilization: A retrospective study
Manuscript Source	Invited Manuscript
All Author List	Nathan Kleinman, Tejas Desai and Charuhas Thakar
Funding Agency and Grant Number
Corresponding Author	Nathan Kleinman, PhD, Department of Data Analysis and Research, Kleinman Analytic Solutions, LLC., 405 Cool Valley Dr., Paso Robles, CA 93446, United States. nathan@kleinmansolutions.com
Key Words	Renin-angiotensin aldosterone system inhibitors; Patiromer; Adherence; Hyperkalemia; Proportion of days covered
Core Tip	Increased use and optimal dosing of guideline-recommended renin-angiotensin aldosterone system inhibitors (RAASi) improve patient outcomes in patients with heart failure, chronic kidney disease, and diabetes. However, RAASi use is also associated with increased occurrence of high potassium levels (hyperkalemia). Patiromer is indicated for the treatment of hyperkalemia, and patients taking patiromer are better able to tolerate optimal doses of RAASi than patients not taking patiromer. In this United States study from 2014 to 2019, 3323 patients who were more adherent with patiromer proportion of days covered > 80% used more RAASi than 10124 patients who were less adherent with patiromer (proportion of days covered ≤ 80%).
Citation	Kleinman N, Desa T, Thakar C. Long-term patiromer adherence and renin-angiotensin aldosterone system inhibitor utilization: A retrospective study. World J Nephrol 2026; In press

Received	2025-08-29 05:09
Peer-Review Started	2025-08-29 05:09
First Decision by Editorial Office Director	2025-10-13 08:52
Return for Revision	2025-10-13 08:52
Revised	2025-10-27 17:23
Publication Fee Transferred
Second Decision by Editor	2026-01-07 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-07 11:13
Articles in Press	2026-01-07 11:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com