Publication Name	World Journal of Stem Cells
Manuscript ID	113631
Country	China

Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Application of stem cell-derived exosomes in bone and joint diseases: Recent advances enabled by diverse carrier technologies
Manuscript Source	Invited Manuscript
All Author List	Ya-Jun Fu, Jie Jian, Can Liu, Yang-Fei Yi, Yi-Tong Ding, Jie Wen, Yu-Fei Li and Qing-Jun Guo
Funding Agency and Grant Number	Funding Agency Grant Number Science Project of Hunan Provincial Healthy Commission 20230844
Corresponding Author	Jie Wen, Associate Professor, Department of Pediatric Orthopedics, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, No. 61 Jiefang West Road, Changsha 410013, Hunan Province, China. cashwj@qq.com
Key Words	Bone and joint diseases; Osteoarthritis; Stem cell-derived exosomes; Delivery systems; Biomaterial scaffolds
Core Tip	Bone and joint diseases, such as osteoarthritis, exhibit significant pathological complexity. Current treatment modalities possess notable limitations, driving the development of cell-free regenerative treatment strategies centered on stem cell-derived exosomes, particularly mesenchymal stem cell-derived exosomes. Despite the promise of mesenchymal stem cell-derived exosomes, several challenges impede their clinical translation. In recent years, optimizing exosome functionality and achieving precise delivery through carrier technologies has emerged as a pivotal strategy to overcome these barriers. This review systematically evaluates the latest advancements in cutting-edge carrier technologies. Looking ahead, multimodal delivery systems integrating gene editing, intelligent responsive materials, and personalized treatment strategies are expected to revolutionize bone and joint disease treatment by transitioning from symptom alleviation to functional reconstruction.
Citation	Fu YJ, Jian J, Liu C, Yi YF, Ding YT, Wen J, Li YF, Guo QJ. Application of stem cell-derived exosomes in bone and joint diseases: Recent advances enabled by diverse carrier technologies. World J Stem Cells 2025; In press

Received	2025-08-31 05:59
Peer-Review Started	2025-08-31 05:59
To Make the First Decision
Return for Revision	2025-09-12 06:58
Revised	2025-09-25 11:27
Second Decision	2025-11-05 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-05 08:40
Articles in Press	2025-11-05 08:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com