Publication Name	World Journal of Clinical Cases
Manuscript ID	113655
Country	Egypt

Category	Infectious Diseases
Manuscript Type	Case Report
Article Title	First use of nitazoxanide in Kelleni’s protocol for managing severe bronchiolitis in a 9-month-old infant: A case report and review of literature
Manuscript Source	Invited Manuscript
All Author List	Mina Thabet Kelleni
Funding Agency and Grant Number
Corresponding Author	Mina Thabet Kelleni, Assistant Professor, MD, PhD, Department of Medical Pharmacology, College of Medicine, Minia University, Main Road Shalaby Land, Minya 61519, Egypt. mina.kelleni@mu.edu.eg
Key Words	SARS-CoV-2; COVID-19; Nitazoxanide; Benproperine; Alpha-amylase; Levocetrizine; Ambroxol; Kelleni’s protocol; Case report
Core Tip	This report presents the first documented use of nitazoxanide incorporated within Kelleni’s protocol to manage severe bronchiolitis in a 9-month-old infant. The infant presented with SpO₂ 84% on room air, tachypnea, and diffuse wheezing which was clinically consistent with severe viral bronchiolitis. Bronchiolitis is a leading cause of infant hospitalization and mortality worldwide, with limited effective antiviral treatments. Early administration of nitazoxanide, alongside other immunomodulatory therapies, showed clinical improvement as shown with resolution of fever and progressive improvement in in all symptoms, SpO₂ rising from 84% to 92% and then 96% at full recovery in this severe case within two weeks. This approach highlights the potential to repurpose nitazoxanide and Kelleni’s protocol to safely manage severe lower viral respiratory tract infections in infants younger than one year.
Citation	Kelleni MT. First use of nitazoxanide in Kelleni’s protocol for managing severe bronchiolitis in a 9-month-old infant: A case report and review of literature. World J Clin Cases 2025; In press

Received	2025-09-01 06:46
Peer-Review Started	2025-09-01 06:46
First Decision by Editorial Office Director	2025-10-17 07:28
Return for Revision	2025-10-17 07:28
Revised	2025-10-31 06:39
Publication Fee Transferred
Second Decision by Editor	2025-12-15 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-15 07:01
Articles in Press	2025-12-15 07:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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