Publication Name	World Journal of Hepatology
Manuscript ID	113660
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Integrated serum metabolomics reveal molecular mechanism of Xietu Hemu prescription on metabolic dysfunction-associated steatotic liver disease-related obesity
Manuscript Source	Unsolicited Manuscript
All Author List	Zhe Cheng, Yi-Fan Lu, Yi-Xian He, Wei Wei, Yi-Xuan Xie, Tian-Su Lv, Yi Wei, Yan Lou, Jiang-Yi Yu and Xi-Qiao Zhou
Funding Agency and Grant Number	Funding Agency Grant Number Jiangsu Postgraduate Research and Practice Innovation Programme KYCX24_2242 Science and Technology Project of Jiangsu Provincial Hospital of Traditional Chinese Medicine Y22002 Forth Batch of Construction Program for Inheritance Office of Jiangsu Province Famous Traditional Chinese Medicine Experts [2021]7
Corresponding Author	Xi-Qiao Zhou, Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, Qinhuai District, Nanjing, Nanjing 210000, Jiangsu Province, China. zhouxiqiao@njucm.edu.cn
Key Words	Xietu Hemu prescription; Metabolic dysfunction-associated steatotic liver disease; Obesity; Lipotoxicity; Leptin
Core Tip	Xietu Hemu prescription, a traditional Chinese medicine formula, ameliorates metabolic dysfunction-associated steatotic liver disease-related obesity by inhibiting adipogenesis. Integrating serum metabolomics, transcriptomics, and network analysis, this study identified the LEP/AMPK/PPARγ signaling axis as the central mechanism. The formula promotes leptin autocrine secretion, activates AMPK phosphorylation, and subsequently downregulates PPARγ and SREBPs, thereby reducing lipid accumulation and improving metabolic homeostasis, offering a novel multi-target therapeutic strategy.
Citation	Cheng Z, Lu YF, He YX, Wei W, Xie YX, Lv TS, Wei Y, Lou Y, Yu JY, Zhou XQ. Integrated serum metabolomics reveal molecular mechanism of Xietu Hemu prescription on metabolic dysfunction-associated steatotic liver disease-related obesity. World J Hepatol 2025; In press

Received	2025-09-01 09:08
Peer-Review Started	2025-09-01 09:09
To Make the First Decision
Return for Revision	2025-09-20 10:51
Revised	2025-10-22 04:10
Second Decision	2025-11-21 08:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-21 09:18
Articles in Press	2025-11-21 09:18
Publication Fee Transferred	2025-10-24 03:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com