Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	113666
Country	Malaysia

Category	Endocrinology & Metabolism
Manuscript Type	Case Report
Article Title	Rare coexistence of aldosterone resistance and adrenal insufficiency in asymptomatic infant with persistent hyperkalaemia: A case report
Manuscript Source	Invited Manuscript
All Author List	Fazila H Wan-Nik, Hani A Zulkeflee, Nadirah S Ab Rahim and Salwani T Tuan-Ismail
Funding Agency and Grant Number
Corresponding Author	Salwani T Tuan-Ismail, Associate Professor, Endocrinology Unit, Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia. tusti@usm.my
Key Words	Hyperkalemia; Aldosterone resistance; Adrenal insufficiency; Electrolyte imbalance; Diagnosis; Case report
Core Tip	A 6-month-old male was incidentally found to have persistent hyperkalaemia despite being asymptomatic with normal electrocardiogram documented during hospitalization for bronchiolitis. Laboratory evaluation showed elevated serum aldosterone, suppressed plasma renin activity, normal serum sodium and chloride with low serum bicarbonate, consistent with aldosterone resistance. Additionally, a short synacthen test confirmed adrenal insufficiency, with normal serum 17-hydroxyprogesterone excluding (congenital adrenal hyperplasia). He required escalating fludrocortisone alongside hydrocortisone and potassium binders, indicating mineralocorticoid resistance. Genetic testing was not performed, but clinical and biochemical findings strongly support coexisting aldosterone resistance and adrenal insufficiency; an exceptionally rare dual endocrinopathy.
Citation	Wan-Nik FH, Zulkeflee HA, Ab Rahim NS, Tuan-Ismail ST. Rare coexistence of aldosterone resistance and adrenal insufficiency in asymptomatic infant with persistent hyperkalaemia: A case report. World J Clin Pediatr 2026; In press

Received	2025-09-01 06:42
Peer-Review Started	2025-09-01 06:42
First Decision by Editorial Office Director	2025-09-25 08:32
Return for Revision	2025-09-25 08:32
Revised	2025-11-02 04:14
Publication Fee Transferred
Second Decision by Editor	2026-01-09 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-09 08:21
Articles in Press	2026-01-09 08:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com