Publication Name	World Journal of Clinical Oncology
Manuscript ID	113674
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	Perineural invasion in digestive tract tumors: Immune system interactions and therapeutic strategies
Manuscript Source	Invited Manuscript
All Author List	Jia-Yu Pang, Rong-Yao Jin, Han-Xiao Zhang, Ying-Hua Zhang, Xin-Yue Wei, Wen-Bo Cao, Yi-Xiao Chen, Jun-Ling Wang and Sai-Jun Mo
Funding Agency and Grant Number	Funding Agency Grant Number Foundation of Henan Educational Committee 26A310017 College Student Innovation and Entrepreneurship Competitions S202510459221, 2025cxcy639 Natural Science Foundation of Henan 242300421493 the Medical Science and Technology Planning Project of Henan Province LHGJ20220525
Corresponding Author	Sai-Jun Mo, Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, No. 100 Science Avenue, Zhongyuan District, Zhengzhou 450001, Henan Province, China. sjmo@zzu.edu.cn
Key Words	Digestive tract tumors; Perineural invasion; Immune system; Tumor microenvironment; Immunotherapy
Core Tip	Digestive tract tumors remain a major global health burden with high morbidity and mortality. Perineural invasion (PNI), the infiltration of tumor cells along nerves, is a key determinant of tumor aggressiveness and poor outcome. This review systematically investigates the crosstalk between PNI and immune mechanisms in gastrointestinal cancers, with a focus on critical components, including the PD-L1/PD-1 axis, T cells, macrophages, and other immune checkpoints. It reveals mechanisms by which PNI reshapes the tumor immune microenvironment to promote metastasis, identify candidate immunotherapeutic targets, and provide a foundation for developing precision treatment strategies.
Citation	Pang JY, Jin RY, Zhang HX, Zhang YH, Wei XY, Cao WB, Chen YX, Wang JL, Mo SJ. Perineural invasion in digestive tract tumors: Immune system interactions and therapeutic strategies. World J Clin Oncol 2025; In press

Received	2025-09-02 04:57
Peer-Review Started	2025-09-02 04:57
First Decision by Editorial Office Director	2025-10-13 08:16
Return for Revision	2025-10-13 08:16
Revised	2025-10-24 14:29
Publication Fee Transferred
Second Decision by Editor	2025-12-19 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-19 07:42
Articles in Press	2025-12-19 07:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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