Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	113681
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Hepatic artery infusion chemotherapy for advanced hepatocellular carcinoma with obstructive jaundice: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Li Zhang, Pan Xiao, Lian-Dong Shi, Ke-Xin Chen and You-Fu Bing
Funding Agency and Grant Number
Corresponding Author	Pan Xiao, Research Fellow, Researcher, Department of Minimally Invasive Interventional Radiology, Guilin People’s Hospital, No. 12 Wenming Road, Xiangshan District, Guilin 541000, Guangxi Zhuang Autonomous Region, China. xp13807836988@163.com
Key Words	Hepatocellular carcinoma; Obstructive jaundice; Hepatic artery perfusion chemotherapy; Portal vein tumor thrombosis; Case report
Core Tip	Hepatocellular carcinoma with portal vein tumor thrombosis (PVTT) and obstructive jaundice is rare and generally carries a poor prognosis. In this case, hepatic artery infusion chemotherapy (HAIC) followed by targeted immunotherapy achieved significant tumor shrinkage, improved bilirubin levels, and regression of PVTT. The patient attained 20 months of progression-free survival and 29 months of overall survival, indicating that HAIC conversion therapy followed by targeted immunotherapy may provide an effective option when biliary drainage is not feasible.
Citation	Zhang L, Xiao P, Shi LD, Chen KX, Bing YF. Hepatic artery infusion chemotherapy for advanced hepatocellular carcinoma with obstructive jaundice: A case report and review of literature. World J Gastrointest Oncol 2025; In press

Received	2025-09-07 14:58
Peer-Review Started	2025-09-07 14:59
To Make the First Decision
Return for Revision	2025-10-11 08:17
Revised	2025-10-22 20:27
Second Decision	2025-11-17 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-17 23:52
Articles in Press	2025-11-17 23:52
Publication Fee Transferred	2025-10-24 09:20
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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