Publication Name	World Journal of Hepatology
Manuscript ID	113685
Country	Slovakia

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Adipokine profiles reflect metabolic dysfunction but not fibrosis in patients with primary biliary cholangitis
Manuscript Source	Invited Manuscript
All Author List	Tomas Koky, Sylvia Drazilova, Slavomira Komarova, Marian Macej, Dominika Toporcerova, Martin Janicko, Ivana Spakova, Miroslava Rabajdova, Maria Marekova and Peter Jarcuska
Funding Agency and Grant Number
Corresponding Author	Sylvia Drazilova, Associate Professor, MD, PhD, Faculty of Medicine, PJ Safarik University, Trieda SNP 1, Kosice 04011, Slovakia. drazilovasylvia@gmail.com
Key Words	Primary biliary cholangitis; Adipokines; Liver fibrosis; Metabolic dysfunction-associated steatotic liver disease; Metabolic syndrome
Core Tip	Our results show that primary biliary cholangitis (PBC) patients with metabolic dysfunction-associated steatotic liver disease or metabolic syndrome as comorbidities exhibit significantly lower adiponectin levels, higher leptin levels, and an elevated leptin-to-adiponectin ratio within the limited sample size of this study. Thus, adipokines may serve as potential biomarkers for identifying metabolic conditions in PBC. By contrast, no significant associations were observed between adipokine levels and fibrosis severity or biochemical response. Our findings indicate that adipokines, particularly leptin-to-adiponectin ratio may become a promising biomarker for identifying metabolic dysfunction-associated steatotic liver disease in PBC patients.
Citation	Koky T, Drazilova S, Komarova S, Macej M, Toporcerova D, Janicko M, Spakova I, Rabajdova M, Marekova M, Jarcuska P, Toporcerova D. Adipokine profiles reflect metabolic dysfunction but not fibrosis in patients with primary biliary cholangitis. World J Hepatol 2025; In press

Received	2025-09-01 07:15
Peer-Review Started	2025-09-01 07:15
First Decision by Editorial Office Director	2025-10-10 08:59
Return for Revision	2025-10-10 08:59
Revised	2025-10-22 11:40
Publication Fee Transferred
Second Decision by Editor	2025-12-24 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-24 07:24
Articles in Press	2025-12-24 07:24
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ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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