Publication Name	World Journal of Gastroenterology
Manuscript ID	113693
Country	United States

Category	Surgery
Manuscript Type	Meta-Analysis
Article Title	Mac-2 binding protein glycosylation isomer as a novel serum biomarker for recurrence in hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Kyle R Stephens, Megan Wilson, Manting Xu, Jeremy T Gaskins, Gina Genova and Robert C G Martin II
Funding Agency and Grant Number
Corresponding Author	Robert C G Martin II, MD, PhD, Division of Surgical Oncology, Hiram C Polk Jr, MD, Department of Surgery, University of Louisville, 315 E Broadway, Louisville, KY 40202, United States. robert.martin@louisville.edu
Key Words	Hepatocellular carcinoma; Biomarker; Serum; Recurrence; Mac-2 binding protein glycosylation isomer
Core Tip	Predicting tumor recurrence following curative treatment for hepatocellular carcinoma (HCC) remains a challenging task. Numerous novel biomarkers have been investigated for their ability to predict disease prognosis, as there is a clear need for noninvasive serum assays that can reliably assess the risk for post-treatment recurrence. Mac-2 binding protein glycosylation isomer (M2BPGi) has emerged as a serum biomarker for liver fibrosis, an important component of HCC pathogenesis. Our meta-analysis demonstrates M2BPGi’s utility as a pre-operative predictor of HCC recurrence.
Citation	Stephens KR, Wilson M, Xu M, Gaskins JT, Genova G, Martin II RCG. Mac-2 binding protein glycosylation isomer as a novel serum biomarker for recurrence in hepatocellular carcinoma. World J Gastroenterol 2025; In press

Received	2025-09-01 09:46
Peer-Review Started	2025-09-01 09:48
First Decision by Editorial Office Director	2025-10-18 02:31
Return for Revision	2025-10-18 02:31
Revised	2025-10-31 21:27
Publication Fee Transferred
Second Decision by Editor	2025-12-22 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-22 07:49
Articles in Press	2025-12-22 07:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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